What Is Nephrotic Syndrome?
Nephrotic syndrome is a kidney disorder marked by massive protein loss in the urine, low blood albumin, severe swelling, and high cholesterol. It’s not a disease itself but a sign that the kidney’s filtering units - called glomeruli - are damaged. Normally, these filters keep proteins like albumin in the blood. When they break down, proteins leak into the urine, pulling fluid with them and causing swelling.
The hallmark signs are easy to spot: foamy urine from excess protein, rapid weight gain from fluid buildup, and puffiness around the eyes, especially in the morning. In adults, swelling often shows up in the ankles and legs. In kids, it starts in the face. Blood tests will show albumin levels below 3.0 g/dL, and cholesterol often climbs above 300 mg/dL. Without treatment, this can lead to blood clots, infections, and even kidney failure.
Why Does Proteinuria Happen?
Proteinuria in nephrotic syndrome isn’t just a number - it’s a breakdown in the kidney’s defense system. The glomeruli have tiny foot-like cells called podocytes that wrap around blood vessels. Between them are slit diaphragms made of proteins like nephrin and podocin. When these proteins are damaged - by immune attacks, genetics, or toxins - the filter becomes leaky.
In children, the most common cause is minimal change disease, where podocytes look normal under a microscope but function poorly. In adults, it’s often focal segmental glomerulosclerosis (FSGS) or membranous nephropathy. Diabetes and lupus can also trigger it. The bigger the protein leak - usually more than 3.5 grams a day in adults - the worse the swelling and risk of complications.
Differentiating Nephrotic from Nephritic Syndrome
Many people confuse nephrotic syndrome with nephritic syndrome, but they’re very different. Nephrotic syndrome is about protein loss and swelling. Nephritic syndrome is about blood in the urine and high blood pressure.
In nephritic syndrome, you’ll see red blood cell casts in the urine, reduced kidney function, and often sudden swelling. It’s usually caused by inflammation like post-strep glomerulonephritis or vasculitis. Nephrotic syndrome doesn’t typically cause high blood pressure or visible blood in the urine - unless there’s another problem. Getting this right matters because the treatments are completely different.
Who Gets Nephrotic Syndrome?
It hits kids and adults differently. In children, about 85% of cases are minimal change disease, mostly between ages 2 and 6. Boys are slightly more likely to be affected. In adults, the causes shift: FSGS makes up 40%, membranous nephropathy 30%, and diabetes 20-30%. Older adults with diabetes are at highest risk.
Genetic forms are rare but serious. Congenital nephrotic syndrome, caused by NPHS1 gene mutations, shows up in babies under 3 months with protein loss over 10 grams a day. These cases don’t respond to steroids and often need early kidney transplant.
Secondary causes include infections like hepatitis B or C, certain drugs like NSAIDs or penicillamine, and autoimmune diseases like lupus. If you’re an adult with new swelling and proteinuria, your doctor will check for these before assuming it’s primary kidney disease.
How Is It Diagnosed?
Diagnosis starts with a urine test. A dipstick showing 3+ or 4+ protein is a red flag. But the gold standard is a 24-hour urine collection - if it shows more than 3.5 grams of protein, nephrotic syndrome is likely.
Blood tests confirm low albumin (<3.0 g/dL) and high cholesterol. A kidney ultrasound may be done to rule out blockages, but it won’t show the damage itself. The real answer often comes from a kidney biopsy - especially in adults, or if steroids don’t work.
Biopsies tell you exactly what’s wrong: minimal change, FSGS, membranous, or something else. This guides treatment. For kids under 6 with classic symptoms, doctors often skip the biopsy and start steroids right away - the response rate is so high it’s practically diagnostic.
First-Line Treatment: Steroids and Response Rates
For children with minimal change disease, prednisone is the go-to. A typical dose is 60 mg/m² per day (up to 80 mg) for 4 to 6 weeks, then slowly tapered over months. About 90% of kids go into remission within 4 weeks.
Adults get similar drugs but respond slower. About 60-70% respond to steroids, but many relapse. The dose is usually 1 mg/kg per day (max 80 mg) for 8 to 16 weeks. Even when it works, relapses happen in half of adults. That’s why doctors watch closely after stopping treatment.
Side effects are real. Kids gain weight, get moon face, and become hungrier. Some become moody or sleep poorly. Parents often mistake these for normal behavior - but they’re drug effects. The key is to use the lowest effective dose for the shortest time.
What If Steroids Don’t Work?
When a patient doesn’t respond after 16 weeks, it’s called steroid-resistant nephrotic syndrome. This happens in 10-15% of kids and up to 30% of adults. The next step is usually a calcineurin inhibitor like tacrolimus or cyclosporine.
Tacrolimus works by calming the immune system’s attack on podocytes. Doses are tight: 0.05 to 0.1 mg/kg per day. Blood levels must be checked regularly to avoid kidney damage from the drug itself. About 60-70% of steroid-resistant patients respond to this.
Rituximab, a drug that targets B-cells, is now used in both kids and adults who relapse often. It’s given as weekly IV infusions for 4 weeks. Many patients stay in remission for over a year. It’s expensive - $1,200 to $2,500 per month - but can cut down on steroid use and side effects.
Diet and Lifestyle: What You Can Do
Medication isn’t the whole story. Diet plays a big role. Sodium restriction to under 2,000 mg per day can cut swelling by 30-50% in just 72 hours. That means no processed foods, canned soups, or salty snacks.
Protein intake needs balance. Too little can cause muscle loss. Too much can make the kidneys work harder. The sweet spot is 0.8 to 1.0 gram per kilogram of body weight. So a 70 kg adult needs about 56-70 grams of protein daily - enough from eggs, lean meat, and beans.
Fluid intake isn’t usually restricted unless swelling is extreme. But weight monitoring is critical. A sudden 2-pound gain in a day could mean fluid buildup. Daily weights are one of the best tools families have to catch relapses early.
Monitoring Progress and Recognizing Relapse
Remission means three days in a row of negative or trace protein on a urine dipstick. Relapse is three days of 2+ or 3+ protein. Parents are taught to test urine weekly during active disease.
Doctors also track albumin and cholesterol. If albumin rises above 3.0 g/dL and cholesterol drops below 200 mg/dL, it’s a good sign. Blood pressure must stay under 130/80 - ACE inhibitors or ARBs are often prescribed for this, even if blood pressure is normal. They reduce protein leakage directly.
Relapses are common - especially after colds or flu. That’s why vaccines matter. Inactivated shots like flu and pneumonia are safe. Live vaccines like MMR or chickenpox are off-limits during steroid treatment. Always check with your nephrologist before any shot.
Big Risks: Blood Clots and Infections
Nephrotic syndrome turns your blood into a clotting hazard. Low albumin means the body makes more clotting proteins. Up to 40% of adults with albumin below 2.0 g/dL develop blood clots - in the legs, lungs, or even the kidney vein itself.
Anticoagulants like warfarin or low-molecular-weight heparin are often used in high-risk cases. But this isn’t routine - it’s reserved for those with severe hypoalbuminemia, immobility, or prior clots.
Infections are another danger. Kids with nephrotic syndrome are 3-5 times more likely to get bacterial infections, especially peritonitis. That’s why some doctors give daily penicillin during active disease. Fever or abdominal pain? Don’t wait - get checked fast.
New Treatments on the Horizon
Research is moving fast. The FDA approved budesonide (Tarpeyo) in 2023 for IgA nephropathy - and it’s showing promise in some FSGS cases, cutting proteinuria by up to 59%.
Sparsentan, a new dual-blocker drug, reduced proteinuria by 47.6% in a 2022 trial - far better than older ARBs. It’s now under review for broader use.
Gene testing is becoming standard for babies under 1 year or those with family history. If it’s a genetic form, avoiding harsh immunosuppressants can save lives. The NEPTUNE study is already identifying molecular subtypes of FSGS that predict who will respond to which drug - paving the way for personalized treatment.
Long-Term Outlook
Prognosis depends entirely on the cause. Minimal change disease has a 95% 10-year kidney survival rate. Most kids outgrow it. FSGS is tougher - 50-70% keep functioning kidneys after 10 years. Membranous nephropathy is in between, at 60-80%. But if diabetes caused it, survival drops to 40-50%.
The biggest red flag? Persistent proteinuria over 1 gram per day after treatment. That increases the risk of kidney failure by more than four times. Complete remission - not partial - is the goal. That’s why sticking to meds, diet, and monitoring matters more than anything.
Can nephrotic syndrome be cured?
In many cases, especially in children with minimal change disease, nephrotic syndrome can go into long-term remission with treatment. Some kids never relapse after stopping medication. But for others - especially adults with FSGS or diabetes - it’s a chronic condition that needs ongoing management. The goal isn’t always a cure, but keeping proteinuria low and protecting kidney function.
Is nephrotic syndrome hereditary?
Most cases are not inherited. But certain rare forms, like congenital nephrotic syndrome of the Finnish type, are caused by gene mutations passed from parents to child. If a child develops nephrotic syndrome before age 1, or if there’s a family history, genetic testing is recommended to avoid unnecessary treatments.
Can I still exercise with nephrotic syndrome?
Yes - unless you have severe swelling, high blood pressure, or recent blood clots. Light to moderate activity like walking or swimming helps maintain muscle, control weight, and improve mood. Avoid heavy lifting or contact sports if you’re on blood thinners or have low platelets. Always check with your doctor before starting a new routine.
Why does my child keep relapsing?
Viral infections - like colds, flu, or ear infections - are the top trigger for relapses in children. The immune system’s response seems to reactivate the kidney damage. That’s why doctors recommend prompt treatment of infections and staying up-to-date on vaccines. Some families learn to start a short steroid burst at the first sign of illness to prevent full relapse.
How do I know if the treatment is working?
Look for three things: less swelling, clearer urine (less foam), and steady weight loss. Blood tests will show albumin rising and cholesterol falling. Urine dipsticks should show negative or trace protein for three days in a row. If protein stays high after 4-6 weeks of steroids, your doctor will consider other treatments.
Next Steps: What to Do Now
If you or your child has been diagnosed, start with three actions: 1) Get a 24-hour urine test and blood work to confirm protein levels and albumin. 2) Talk to your nephrologist about whether a biopsy is needed. 3) Begin a low-sodium diet and track daily weight.
Keep a symptom journal: note swelling, urine foam, appetite changes, and any infections. This helps spot relapses early. Don’t skip follow-ups - even if you feel fine. Kidney damage can creep up silently.
For parents: connect with support groups. Many families find comfort and practical tips from others who’ve been through it. For adults, managing diabetes or high blood pressure is just as important as treating the kidney issue.
Nephrotic syndrome is serious - but with the right care, most people live full, active lives. The key is early action, consistent monitoring, and never giving up on remission.
Hi, I'm Caden Lockhart, a pharmaceutical expert with years of experience in the industry. My passion lies in researching and developing new medications, as well as educating others about their proper use and potential side effects. I enjoy writing articles on various diseases, health supplements, and the latest treatment options available. In my free time, I love going on hikes, perusing scientific journals, and capturing the world through my lens. Through my work, I strive to make a positive impact on patients' lives and contribute to the advancement of medical science.