Flagyl sometimes doesn’t cut it for stubborn C. difficile or trichomoniasis infections, leaving people stuck wondering what's next. This article uncovers why Flagyl might fail, explores the latest Australian and global treatment guidelines, and breaks down next-line therapies in clear, real-world language. Find out about new antibiotics, probiotics, and non-medicine approaches catching attention in 2025. Concrete tips and direct, honest facts at every step make sure you walk away with hope and a clear plan.